Functional consequence of the MET-T1010I polymorphism in breast cancer.

Major breast cancer predisposition genes, only account for approximately 30% of high-risk breast cancer families and only explain 15% of breast cancer familial relative risk. The HGF growth factor receptor MET is potentially functionally altered due to an uncommon germline single nucleotide polymorphism (SNP), MET-T1010I, in many cancer lineages including breast cancer where the MET-T1010I SNP is present in 2% of patients with metastatic breast cancer. Expression of MET-T1010I in the context of mammary epithelium increases colony formation, cell migration and invasion in-vitro and tumor growth and invasion in-vivo. A selective effect of MET-T1010I as compared to wild type MET on cell invasion both in-vitro and in-vivo suggests that the MET-T1010I SNP may alter tumor pathophysiology and should be considered as a potential biomarker when implementing MET targeted clinical trials

Safety and Immunogenicity of a Malaria Vaccine, Plasmodium falciparum AMA-1/MSP-1 Chimeric Protein Formulated in Montanide ISA 720 in Healthy Adults

The P. falciparum chimeric protein 2.9 (PfCP-2.9) consisting of the sequences of MSP1-19 and AMA-1 (III) is a malaria vaccine candidate that was found to induce inhibitory antibodies in rabbits and monkeys. This was a phase I randomized, single-blind, placebo-controlled, dose-escalation study to evaluate the safety and immunogenicity of the PfCP-2.9 formulated with a novel adjuvant Montanide ISA720. Fifty-two subjects were randomly assigned to 4 dose groups of 10 participants, each receiving the test vaccine of 20, 50, 100, or 200 µg respectively, and 1 placebo group of 12 participants receiving the adjuvant only.The vaccine formulation was shown to be safe and well-tolerated, and none of the participants withdrew. The total incidence of local adverse events (AEs) was 75%, distributed among 58% of the placebo group and 80% of those vaccinated. Among the vaccinated, 65% had events that were mild and 15% experienced moderate AEs. Almost all systemic adverse reactions observed in this study were graded as mild and required no therapy. The participants receiving the test vaccine developed detectable antibody responses which were boosted by the repeated vaccinations. Sixty percent of the vaccinated participants had high ELISA titers (>1∶10,000) of antigen-specific antibodies which could also recognize native parasite proteins in an immunofluorescence assay (IFA).This study is the first clinical trial for this candidate and builds on previous investigations supporting PfCP-2.9/ISA720 as a promising blood-stage malaria vaccine. Results demonstrate safety, tolerability (particularly at the lower doses tested) and immunogenicity of the formulation. Further clinical development is ongoing to explore optimizing the dose and schedule of the formulation to decrease reactogenicity without compromising immunogenicity.

Price Volatility Transmission in China’s Hardwood Lumber Imports

Hardwood lumber is the principal part of the global hardwood timber trade. China has become the largest importer of hardwood lumber in the world. However, China’s hardwood lumber imports are affected by price volatility. Thus, we investigated the price volatility transmission of China’s hardwood lumber imports. We aimed to detect the source, path, and intensity of the volatility transmission in China’s hardwood lumber imports, and reveal the intrinsic interactions between price volatilities. To date, there is little research on the price fluctuations of forest products. This paper provides an empirical analysis on the volatility transmission in China’s forest product imports. We selected four types of major hardwood lumber imports to China; that is, teak (Tectona grandis L.F.), merbau (Merbau), sapele (Entandrophragma), and casla (Terminalia spp.) (The Latin names of tree species are given in parentheses), and used their daily prices from 4 August 2010 to 15 April 2020. The Baba–Engle–Kraft–Kroner (BEKK) multivariate models and dynamic conditional correlation (DCC) models were employed. The empirical results indicate that there is an intrinsic relationship between the price fluctuations in China’s hardwood lumber imports. The volatility transmission chain originates from casla; it is transmitted along the casla→sapele→merbau→teak pathway. The direction of transmission is from lower prices to higher prices. The dynamic conditional correlation of each link in the chain does not exhibit any particular time trend. This suggests that volatility transmission is a crucial price mechanism in China’s hardwood lumber imports. Our findings have important policy implications for hedging timber price risks and designing timber trade policies

Can Agricultural Machinery Harvesting Services Reduce Cropland Abandonment? Evidence from Rural China

Ending hunger, achieving food security, and promoting sustainable agriculture are the main targets of sustainable development goals. It is well known that cropland resources are the most essential factor in achieving sustainable development goals. However, China has been facing the problem of a continuous reduction in cropland resources. Reducing the abandonment of cropland has become an important way to curb the reduction in cropland resources. Can agricultural machinery harvesting services reduce cropland abandonment in rural China? To answer this scientific question, this study employs the Survey for Agriculture and Village Economy data from 8345 samples of 12 provinces in rural China. The extended regression models (i.e., the extended probit regression model and the extended interval regression model) are used to empirically analyze the relationship between agricultural machinery harvesting services accessed by farmers and cropland abandonment. The results are as follows. Agricultural machinery harvesting services accessed by farmers significantly reduced the probability of cropland abandonment and the proportion of the area of abandoned cropland in farmers’ contracted cropland area decreased by 18.5% and 20.3%, respectively. Moreover, the heterogeneity analysis results showed that farmers’ access to agricultural machinery harvesting services significantly reduced cropland abandonment in small-scale groups, without elderly households, with nonagricultural income groups, and in the eastern region. This study also provides some policy implications for policymakers to reduce cropland abandonment in rural China